Ability Biologics

Latest News
NEW CHIEF MEDICAL OFFICER
We are delighted to welcome Dr. Elizabeth Quackenbush as our Chief Medical Officer, strengthening our team at a pivotal moment in Ability’s journey.
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Ability develops logic-gated biotherapeutics to address unmet medical needs in patients with cancer and autoimmune diseases

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Our AbiLeap™ discovery engine applies generative AI to systematically create fully human antibody therapeutics with unparalleled specificity

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Our antibodies are conditionally activated, targeting specific cells and disease sites such as the tumor microenvironment

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Our approach enables solutions for reducing toxicity and significantly broadening the therapeutic window to optimize treatment benefits for patients

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We are dedicated to revolutionizing targeted therapeutics to transform patient outcomes and redefine industry standards.

About Ability

Our mission

Develop innovative, targeted, immune modulating biotherapeutics to address unmet medical needs in patients with cancer and autoimmune diseases.


The premier biotherapeutic targeting company

Our powerful AbiLeap™ discovery engine combines massively parallel, continuously learning artificial intelligence (AI) with an extensive database of antigen-antibody interactions to generate fully human, IgG-based multispecific antibodies of exquisite selectivity and affinity.

The antibodies respond to environmental signals within the cellular microenvironment, generating logic-gated therapeutics. We are dedicated to developing the most potent and selective antibody therapeutics for areas of great unmet need. To learn more, contact us at .

Approach

Technology: Contextually-gated antibodies as next generation targeted biotherapeutics

Ability utilizes its proprietary AbiLeap™ discovery platform to generate logic-enabled antibodies that harbour contextual abilities to engage with key immune pathways. Ability is developing several preclinical antibody candidates with an exquisite selectivity for specific immune subpopulations and oncology targets, providing greater specificity and a broadened therapeutic window across a range of indications.

The AbiLeap™ platform layers generative AI over one of the largest, ML-ready antibody therapeutics discovery databases. The resulting discovery engine allows Ability to produce libraries of fully human therapeutic ready antibodies specifically designed to achieve contextual binding, enabling the generation of highly specific and selective antibodies.

Applications: Immune Modulators

We are focused on developing best-in-class and first-in-class immune modulators against targets with broad therapeutic applicability. Therapeutic assets are selected based on unique efficacy for rapid manufacturing and deployment in the clinical setting and for broad relevance across cancer and auto-immune applications where safer and more effective treatments are lacking. Ability will develop its drug candidates through human proof of concept clinical trials.

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Pipeline

Ability is currently moving forward 4 biotherapeutic candidates in the fields of immuno-oncology, solid tumors and autoimmune diseases


Antibody Indication Discovery Develop Preclinical POC
Leap 1121 Autoimmune
Leap 1009 IO / Solid Tumors
Leap 1030 IO / Solid Tumors
Undisclosed Autoimmune & IO
Antibody & Indication Discovery Develop Preclinical POC
Leap 1121
Autoimmune
Leap 1009
IO / Solid Tumors
Leap 1030
IO / Solid Tumors
Undisclosed
Autoimmune & IO

Legend: Disc: Discovery, Dev: Develop, Pre: Preclinical POC
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Management Team

Our executive team has an extensive experience in antibody discovery and development programs and successfully taken multiple products through clinical development.


Image of Giles Day

Giles Day

M.Sc.
Chief Executive Officer
Giles Day
M.Sc.
Chief Executive Officer

Co-founder and CEO of Distributed Bio, Giles is an expert at building high performing capital efficient teams. He organically built Distributed Bio from 2 employees in 2010 to 30 in 2020, by structuring over 50 partnerships and licensing deals. He led the acquisition of Distributed Bio by Charles River Laboratories for over $100M up front with milestones and royalties. Prior to Distributed Bio Giles spent 15 years at Pfizer, where he held the position of Head of Informatics for the Biotherapeutics and Bioinnovation division. Giles holds a MSc in Computational Biology from the University of Manchester.

Jean-Philippe Bürckert
M.Sc., Ph.D.
Chief Technology Officer

Jean-Philippe oversees the design strategies for the discovery and engineering programs as well as establishing the IP portfolio. Previously, JP was the Director of Bioinformatics at Charles River laboratories in South San Francisco, heading the scientific steering committee and R&D efforts at the site. Before that, he established the first US department of the international Bioinformatics, statistics and ML consulting firm BISC Global. He holds a PhD in computational immunology from the Luxembourg Institute of Health as well as a MSc in Biochemistry from the Technical University of Kaiserslautern. JP has accumulated over a decade of experience in immunoinformatics with a focus on antibody discovery and engineering.

Image of Patrick Tremblay

Patrick Tremblay

Ph.D.
Chief Operating Officer
Patrick Tremblay
Ph.D.
Chief Operating Officer

Patrick is an executive with broad expertise in R&D and corporate development. He supports operations as well as strategic initiatives. Patrick was the Chief Corporate Development Officer at CellCarta where he led M&A activities completing 6 global acquisitions (for more than US$ 250M), diversifying services and growing the company across 10 sites and 3 continents. Prior to that, Patrick worked with Pappas Ventures, a venture capital firm investing in North American life sciences. He also held positions as Vice-President of R&D at BioAxone and as Director of Pharmacology at Neurochem where he worked on the development of drugs for systemic amyloidosis, Alzheimer’s disease and spinal cord injury. He also held a position of Assistant Professor in Neurology at the UCSF where he was part of the Nobel Team of Stanley Prusiner (1997). Patrick holds a Ph.D. in Molecular Biology from Montreal University and completed postdoctoral studies at the Max Planck Institute in Goettingen (Germany).

Image of Patricia Giblin

Patricia Giblin

Ph.D.
Chief Science Officer
Patricia Giblin
Ph.D.
Chief Science Officer

Patti is an experienced leader in drug discovery and development with strong track record for delivering biologic and small molecule candidates into the clinic in immune oncology and immunology. With a focus on understanding mechanism of action and clinical translation, Patti has held leadership positions in two early stage biotechs: Revitope Oncology, a company with a novel T cell engager platform where she led Biology and Northern Biologics where she established the translational sciences and bioanalytical teams while leading the company’s first clinical program. Patti began her career at Boehringer Ingelheim Pharmaceutical where she laid down a strong foundation in R&D, with experience from target identification through Phase I. She obtained her Ph.D. in Immunology from Yale University and conducted her postdoctoral studies at UCSF in the laboratory of Dr. Steven D. Rosen.

Elizabeth Quackenbush
M.D., Ph.D.
Chief Medical Officer

Elizabeth (Betsy) is a physician scientist who obtained her medical degree and PhD (Immunology) from the University of Toronto. Elizabeth completed a residency in internal medicine and a fellowship in Clinical Genetics at the Beth Israel Hospital and Children’s Hospital, respectively, in Boston, as well as a post-doctoral fellowship at the Dana-Farber Cancer Institute. In 2000, Elizabeth begin a 22 year journey in drug development, working in all phases from pre-clinical drug discovery through late stage clinical trial management.

Over the years, Elizabeth has held rising positions of leadership at both large pharmaceutical companies (Merck; Roche) and small biotechnology companies (Agennix; Celldex; and Elstar Therapeutics) and consulted for several more. Although she has worked across many different therapeutic areas (Cardiology, Autoimmunity, Neurology, Genetics), she has focused in the past decade on the development of large molecules and cells as immuno-oncology treatments (in particular, on T-cell engagers) and on gene therapies for rare disorders, working primarily as a Translational Medicine Expert.

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Matthew Clark

Ph.D.
Vice-President
Data Sciences
Matthew Clark
Ph.D.
Vice-President
Data Sciences

Most recently, Matt was Sr. Director and Global Head of Data Analytics at Charles River Labs, where he introduced virtual control groups to in-vivo tests, replace control animals in preclinical studies using data science. Before that he led a global team of data scientists at Elsevier using AI, NLP, GAN and Bayesian statistics to address diverse problems in global drug development. Matt’s pharma experience includes Sr. Director of Computation at Locus Pharma, an AI-based pharma where the computational technology brought two programs to clinical trials as well as at AstraZeneca in safety sciences. He holds a PhD in chemistry from the University of Alabama.

Board of Directors

Ability is privileged to be guided by seasoned investors with a deep understanding of the company’s R&D and business environments.


Image of David de Graaf

David de Graaf

Ph.D.
Executive Chairman
Image of Giles Day

Giles Day

M.Sc.
CEO, Ability Biotherapeutics
Image of Dion Madsen

Dion Madsen

CFA
Partner, Amplitude Ventures
Image of Marc-Olivier Sirard

Marc-Olivier Sirard

CPA-CA
Director, Private Equity and Impact Investing, Fonds de solidarité FTQ
Image of Louis-Etienne Fortier

Louis-Etienne Fortier

CPA
Senior Director, Life Science Investments, Investissement Québec
Image of Angèle Maki

Angèle Maki

PhD
Chief Business Officer, Callio Therapeutics

Our Investors

  • Logo https://amplitudevc.com
  • Logo https://fondsftq.com
  • Logo https://investquebec.com
  • Logo https://criver.com
  • Logo https://seidocapital.com
  • Logo https://are.com/venture-investments.html
  • Logo https://pageone.vc
“Ability’s proprietary platform stands out as it provides an unrivalled way of creating uniquely differentiated, potent, ultra-targeted biotherapeutics with markedly increased specificity and selectivity.”
– Dion Madsen, CFA, Amplitude Ventures

Careers

Ability is frequently looking for talented, skilled professionals to contribute to the company’s development and fulfill its vision.


Project Manager

Category
Full-time, permanent
Location
Montreal (St-Laurent technopark)

News and Media

In this section, you will find our most recent press releases, as well as the articles pertaining to Ability and the events our team will be part of.

Patrick Tremblay (COO) et Jean-Philippe Bürckert (CTO) will attend Bio-Europe in Vienna, Austria
Conference website
Dr. Elizabeth Quackenbush appointed Chief Medical Officer
Read more
Ability produces an article about logic-gated engagers for precision biotherapeutics available in the most recent issue of Biopharma Dealmakers (published by Nature)
Read the article online
Leadership team promotion announcement by Ability Biotherapeutics
Read more
Engineering Smarter Antibodies: A Global Team Anchoring the Future of Immunotherapy in Montreal
Read more
Ability Biotherapeutics Welcomes Angèle Maki, PhD to its Board of Directors
Read more

Contact Us

Headquarters
Ability Biotherapeutics
3 Place Ville Marie
Suite #400
Montreal, QC
H3B 2E3
Canada

510.224.5486
Laboratories
Ability @ adMare Innovation Centre
7171 Frederick-Banting St.
Montreal, QC
H4S 1Z9
Canada

514.375.3334
Ability Biologics Team