Ability Biologics

Latest News
SCIENTIFIC ADVISORY BOARD: NEW MEMBERS
Ability Biotherapeutics Expands its Scientific Advisory Board with the Appointment of Dr. John Burke and Dr. Alan Korman
Slide #1

Ability develops logic-gated biotherapeutics to address unmet medical needs in patients with cancer and autoimmune diseases

Slide #2

Our AbiLeap™ discovery engine applies generative AI to systematically create fully human antibody therapeutics with unparalleled specificity

Slide #3

Our antibodies are conditionally activated, targeting specific cells and disease sites such as the tumor microenvironment

Slide #4

Our approach enables solutions for reducing toxicity and significantly broadening the therapeutic window to optimize treatment benefits for patients

Slide #5

We are dedicated to revolutionizing targeted therapeutics to transform patient outcomes and redefine industry standards.

About Ability

Our mission

Develop innovative, targeted, immune modulating biotherapeutics to address unmet medical needs in patients with cancer and autoimmune diseases.


The premier biotherapeutic targeting company

Our powerful AbiLeap™ discovery engine combines massively parallel, continuously learning artificial intelligence (AI) with an extensive database of antigen-antibody interactions to generate fully human, IgG-based multispecific antibodies of exquisite selectivity and affinity.

The antibodies respond to environmental signals within the cellular microenvironment, generating logic-gated therapeutics. We are dedicated to developing the most potent and selective antibody therapeutics for areas of great unmet need. To learn more, contact us at .

Approach

Technology: Contextually-gated antibodies as next generation targeted biotherapeutics

Ability utilizes its proprietary AbiLeap™ discovery platform to generate logic-enabled antibodies that harbour contextual abilities to engage with key immune pathways. Ability is developing several preclinical antibody candidates with an exquisite selectivity for specific immune subpopulations and oncology targets, providing greater specificity and a broadened therapeutic window across a range of indications.

The AbiLeap™ platform layers generative AI over one of the largest, ML-ready antibody therapeutics discovery databases. The resulting discovery engine allows Ability to produce libraries of fully human therapeutic ready antibodies specifically designed to achieve contextual binding, enabling the generation of highly specific and selective antibodies.

Applications: Immune Modulators

We are focused on developing best-in-class and first-in-class immune modulators against targets with broad therapeutic applicability. Therapeutic assets are selected based on unique efficacy for rapid manufacturing and deployment in the clinical setting and for broad relevance across cancer and auto-immune applications where safer and more effective treatments are lacking. Ability will develop its drug candidates through human proof of concept clinical trials.

technology-image-1
technology-image-2

Pipeline

Ability is currently moving forward 4 biotherapeutic candidates in the fields of immuno-oncology, solid tumors and autoimmune diseases


Antibody Indication Discovery Develop Preclinical POC
Leap 1121 Autoimmune
Leap 1009 IO / Solid Tumors
Leap 1030 IO / Solid Tumors
Undisclosed Autoimmune & IO
Antibody & Indication Discovery Develop Preclinical POC
Leap 1121
Autoimmune
Leap 1009
IO / Solid Tumors
Leap 1030
IO / Solid Tumors
Undisclosed
Autoimmune & IO

Legend: Disc: Discovery, Dev: Develop, Pre: Preclinical POC
Viewing tip: for a better user experience, hold your phone horizontally

Management Team

Our executive team has an extensive experience in antibody discovery and development programs and successfully taken multiple products through clinical development.


Image of Giles Day

Giles Day

M.Sc.
Chief Executive Officer
Giles Day
M.Sc.
Chief Executive Officer

Co-founder and CEO of Distributed Bio, Giles is an expert at building high performing capital efficient teams. He organically built Distributed Bio from 2 employees in 2010 to 30 in 2020, by structuring over 50 partnerships and licensing deals. He led the acquisition of Distributed Bio by Charles River Laboratories for over $100M up front with milestones and royalties. Prior to Distributed Bio Giles spent 15 years at Pfizer, where he held the position of Head of Informatics for the Biotherapeutics and Bioinnovation division. Giles holds a MSc in Computational Biology from the University of Manchester.

Jean-Philippe Bürckert
M.Sc., Ph.D.
Chief Technology Officer

Jean-Philippe oversees the design strategies for the discovery and engineering programs as well as establishing the IP portfolio. Previously, JP was the Director of Bioinformatics at Charles River laboratories in South San Francisco, heading the scientific steering committee and R&D efforts at the site. Before that, he established the first US department of the international Bioinformatics, statistics and ML consulting firm BISC Global. He holds a PhD in computational immunology from the Luxembourg Institute of Health as well as a MSc in Biochemistry from the Technical University of Kaiserslautern. JP has accumulated over a decade of experience in immunoinformatics with a focus on antibody discovery and engineering.

Image of Patrick Tremblay

Patrick Tremblay

Ph.D.
Chief Operating Officer
Patrick Tremblay
Ph.D.
Chief Operating Officer

Patrick is an executive with broad expertise in R&D and corporate development. He supports operations as well as strategic initiatives. Patrick was the Chief Corporate Development Officer at CellCarta where he led M&A activities completing 6 global acquisitions (for more than US$ 250M), diversifying services and growing the company across 10 sites and 3 continents. Prior to that, Patrick worked with Pappas Ventures, a venture capital firm investing in North American life sciences. He also held positions as Vice-President of R&D at BioAxone and as Director of Pharmacology at Neurochem where he worked on the development of drugs for systemic amyloidosis, Alzheimer’s disease and spinal cord injury. He also held a position of Assistant Professor in Neurology at the UCSF where he was part of the Nobel Team of Stanley Prusiner (1997). Patrick holds a Ph.D. in Molecular Biology from Montreal University and completed postdoctoral studies at the Max Planck Institute in Goettingen (Germany).

Image of Patricia Giblin

Patricia Giblin

Ph.D.
Chief Science Officer
Patricia Giblin
Ph.D.
Chief Science Officer

Patti is an experienced leader in drug discovery and development with strong track record for delivering biologic and small molecule candidates into the clinic in immune oncology and immunology. With a focus on understanding mechanism of action and clinical translation, Patti has held leadership positions in two early stage biotechs: Revitope Oncology, a company with a novel T cell engager platform where she led Biology and Northern Biologics where she established the translational sciences and bioanalytical teams while leading the company’s first clinical program. Patti began her career at Boehringer Ingelheim Pharmaceutical where she laid down a strong foundation in R&D, with experience from target identification through Phase I. She obtained her Ph.D. in Immunology from Yale University and conducted her postdoctoral studies at UCSF in the laboratory of Dr. Steven D. Rosen.

Elizabeth Quackenbush
M.D., Ph.D.
Chief Medical Officer

Elizabeth (Betsy) is a physician scientist who obtained her medical degree and PhD (Immunology) from the University of Toronto. Elizabeth completed a residency in internal medicine and a fellowship in Clinical Genetics at the Beth Israel Hospital and Children’s Hospital, respectively, in Boston, as well as a post-doctoral fellowship at the Dana-Farber Cancer Institute. In 2000, Elizabeth begin a 22 year journey in drug development, working in all phases from pre-clinical drug discovery through late stage clinical trial management.

Over the years, Elizabeth has held rising positions of leadership at both large pharmaceutical companies (Merck; Roche) and small biotechnology companies (Agennix; Celldex; and Elstar Therapeutics) and consulted for several more. Although she has worked across many different therapeutic areas (Cardiology, Autoimmunity, Neurology, Genetics), she has focused in the past decade on the development of large molecules and cells as immuno-oncology treatments (in particular, on T-cell engagers) and on gene therapies for rare disorders, working primarily as a Translational Medicine Expert.

Image of Matthew Clark

Matthew Clark

Ph.D.
Vice-President
Data Sciences
Matthew Clark
Ph.D.
Vice-President
Data Sciences

Most recently, Matt was Sr. Director and Global Head of Data Analytics at Charles River Labs, where he introduced virtual control groups to in-vivo tests, replace control animals in preclinical studies using data science. Before that he led a global team of data scientists at Elsevier using AI, NLP, GAN and Bayesian statistics to address diverse problems in global drug development. Matt’s pharma experience includes Sr. Director of Computation at Locus Pharma, an AI-based pharma where the computational technology brought two programs to clinical trials as well as at AstraZeneca in safety sciences. He holds a PhD in chemistry from the University of Alabama.

Board of Directors

Ability is privileged to be guided by seasoned investors with a deep understanding of the company’s R&D and business environments.


Image of David de Graaf

David de Graaf

Ph.D.
Executive Chairman
Image of Giles Day

Giles Day

M.Sc.
CEO, Ability Biotherapeutics
Image of Dion Madsen

Dion Madsen

CFA
Partner, Amplitude Ventures
Image of Marc-Olivier Sirard

Marc-Olivier Sirard

CPA-CA
Director, Private Equity and Impact Investing, Fonds de solidarité FTQ
Image of Louis-Etienne Fortier

Louis-Etienne Fortier

CPA
Senior Director, Life Science Investments, Investissement Québec
Image of Angèle Maki

Angèle Maki

PhD
Chief Business Officer, Callio Therapeutics

Scientific Advisory Board

Together, members of the Scientific Advisory Board provide the critical scientific foundation guiding Ability’s pipeline.


Gerald Batist
MD, FACP
Deputy Director, Segal Cancer Centre, Jewish General Hospital; Director, McGill Centre for Translational Research in Cancer, Lady Davis Institute

Gerald Batist, MD, is Professor of Oncology at McGill University and was University Chair of Oncology for 10 years. He is Deputy Director and leader of the Cancer Axis of the Lady Davis Institute for Medical Research. Dr. Batist led the development of the Segal Cancer Centre, which intimately links research and clinical care and has generated novel treatment models. He co-created the Q-CROC Quebec-wide network and was a co-founder of the WIN global consortium for personalized medicine, which is based in Paris. He is a medical oncologist and molecular pharmacologist, whose research focuses on novel drug development and therapeutic resistance. He has published over 290 papers and book chapters and shares multiple patents for new chemical entities with novel therapeutic potential. Dr. Batist has achieved significant funding for personalized medicine initiatives, leading large groups in biopsy-driven innovative studies designed to identify molecular signatures of resistance and novel therapeutic targets.

John Burke
Ph.D
Chief Pharmacology Officer, Reverb Therapeutics

Dr. Burke is an entrepreneur, pioneer, and leader in the biotech and systems pharmacology industries. He is the Chief Pharmacology Officer at Reverb Therapeutics. Prior to that, he was the CEO and co-founder of Applied BioMath, which after 10 years became the world’s largest systems pharmacology tech-backed services provider and world leader in systems pharmacology software development. Applied BioMath was acquired by Certara in December 2023, and subsequently John became VP of Quantitative Systems Pharmacology Consultancy. Prior to Applied BioMath, he led the Systems Modeling group at Boehringer Ingelheim. John holds a PhD in Mathematics from Arizona State University and was a senior postdoctoral research fellow in the Biological Engineering Department, Massachusetts Institute of Technology, and then in the Systems Biology Department, Harvard Medical School. He is a member of the Drug Discovery Advisory Council, for the Food Allergy Science Initiative (FASI), is on several SABs at small start-up biotechs, and periodically teaches courses geared towards upper level undergraduate and graduate students at local universities.

Alan J. Korman
Ph.D.
Chief Scientific Officer, BlueSphereBIO

Alan Korman, PhD, brings more than three decades of immunotherapy and biotechnology experience to his role as Chief Scientific Officer and Board Member at BlueSphere Bio. Prior to joining BlueSphere, he served as the Senior Vice President of Human Immunology at Vir Biotechnology. Before that, Dr. Korman was the Vice President of Immuno-Oncology Discovery at Bristol-Myers Squibb (BMS). Earlier, he worked at Medarex in roles of increasing responsibility through to Vice President of Discovery Research. While at BMS and Medarex, Dr. Korman led the discovery of the immune checkpoint blockade approaches to cancer immune therapy. He directed the preclinical development of Yervoy and Opdivo and their combination, which significantly impacted countless cancer patients’ lives and meaningfully advanced the field of cancer therapy research. Dr. Korman began his career in the pharmaceutical industry at Supragen and NeXstar Pharmaceuticals, where he served as Director of Immunology.

Dr. Korman received his Ph.D. in Cellular and Developmental Biology from Harvard University, A.M. in Biology from Harvard University and A.B. in Biology from Brandeis University. Following the completion of his education, he was a Fellow at the Whitehead Institute at the Massachusetts Institute of Technology. In addition, Dr. Korman holds more than 30 patents and most notably, played an instrumental role in the discovery of the first anti-CTLA-4 checkpoint inhibitor, the world’s first PD-1 inhibitor nivolumab (anti-PD-1 Opdivo®) and its combination with ipilimumab, as well as the world’s first LAG-3 inhibitor relatlimab (anti-LAG-3) in combination with nivolumab.

John Stagg
Ph.D.
Director, Rosalind and Morris Goodman Cancer Institute

Dr John Stagg is Director of the Rosalind and Morris Goodman Cancer Institute (GCI) at McGill University. Prior to his appointment at GCI he was a professor at McGill University and Lab Head at the CRCHUM since 2010. An established cancer immunologist, John has authored over 100 research publications. Among many breakthroughs John is known for having identified the adenosine-producing enzyme CD73 as a novel target in immuno-oncology and for contributing to the development of therapeutic agents now in Phase 2 clinical trials. His lab has also identified several novel potential targets in immune-oncology to overcome resistance to anti-PD-1/CTLA-4 immune checkpoint blockade. Outside of being a leading academic John is familiar with the biotech environment, being a co-founder and SAB member of Surface Oncology, a clinical-stage biotech. He is a member of the board of directors of BioCanRx, Canada’s immunotherapy network and has received a wide range of distinctions, including a Canadian Institutes of Health Research (CIHR) New Investigator award, the Jean-Guy Sabourin Research Chair in Pharmacology from Faculty of Pharmacy at the Université de Montréal. As a co-leader of the Montreal Cancer Consortium, he played a pivotal role in establishing the Terry Fox Research Institute’s Marathon of Hope Cancer Centres Network, dedicated to accelerating the development of precision medicine.

Our Investors

  • Logo https://amplitudevc.com
  • Logo https://fondsftq.com
  • Logo https://investquebec.com
  • Logo https://criver.com
  • Logo https://seidocapital.com
  • Logo https://are.com/venture-investments.html
  • Logo https://pageone.vc
“Ability’s proprietary platform stands out as it provides an unrivalled way of creating uniquely differentiated, potent, ultra-targeted biotherapeutics with markedly increased specificity and selectivity.”
– Dion Madsen, CFA, Amplitude Ventures

Careers

Ability is frequently looking for talented, skilled professionals to contribute to the company’s development and fulfill its vision.


Project Manager

Category
Full-time, permanent
Location
Montreal (St-Laurent technopark)

News and Media

In this section, you will find our most recent press releases, as well as the articles pertaining to Ability and the events our team will be part of.

Ability Biotherapeutics Expands its Scientific Advisory Board with the Appointment of Dr. John Burke and Dr. Alan Korman
Read more
Dr. Elizabeth Quackenbush appointed Chief Medical Officer
Read more
Ability produces an article about logic-gated engagers for precision biotherapeutics available in the most recent issue of Biopharma Dealmakers (published by Nature)
Read the article online
Leadership team promotion announcement by Ability Biotherapeutics
Read more
Engineering Smarter Antibodies: A Global Team Anchoring the Future of Immunotherapy in Montreal
Read more
Ability Biotherapeutics Welcomes Angèle Maki, PhD to its Board of Directors
Read more

Contact Us

Headquarters
Ability Biotherapeutics
3 Place Ville Marie
Suite #400
Montreal, QC
H3B 2E3
Canada

510.224.5486
Laboratories
Ability @ adMare Innovation Centre
7171 Frederick-Banting St.
Montreal, QC
H4S 1Z9
Canada

514.375.3334
Ability Biologics Team